Animal testing raises questions in two seemingly opposing areas: ethics and science. Despite stricter laws on animal welfare, ethics are fighting a losing battle against the promise of the potential benefits of animal testing to humans. The general public, including many animal lovers, and politicians still hold a firm belief that animal testing is a necessary evil. This makes the use of animals in research a more difficult ethical issue than the use of animals for food. However, animal testing frequently shows little to no benefit and can even cause harm to the human species and therefore hinders the development of treatments and cures. The focus of this talk is to describe the state of the art of alternatives to animal testing and demonstrate how scientific progress can be accelerated without the cruelty of animal testing.