The first part of this presentation looks at the antropocentric approach towards animal experiments. It focuses on recent scientific evolutions and discusses the question: how scientifically reliable are animal experiments in applied biomedical research for human diseases? This first part will be the most extensive of the presentation, as it will be useful for many animal rights activists to get a clearer picture of the technical scientific arguments against animal experiments. The second step is the welfarist approach, where we ask the question: do animal experimenters comply with the 3 R strategy (reduce, refine and replace) and do they lose their moral credibility? The third step briefly discusses the abolitionist approach (antispeciesism).